Before a new technology in the field of health care comes onto the market, it must be clinically tested (validated). With regard to this medical validation, biozoom works with all relevant luminaries from the respective medical faculties.
In the field of determining the antioxidant status measurement, we work with, for example, Prof. Lademann, the head of the Berlin skin physiology (Charité). He is the world's leading scientist in the field of non-invasive measurement of antioxidants and has performed the validation of the meter. In the corresponding study it could be shown that the measured values of the biozoom measuring device agree very well with the measured values of a recognized reference system.
In the field of determining the heart rate variability (HRV) biozoom has a cooperation with Prof. Dr. Thomas Loew, the head of psychosomatic medicine at the Regensburg University Hospital, stated. He is also the chief physician of the psychosomatic ward at the Donaustauf Clinic and, since 2012, has been Vice-President of the Association of European Physicians for Psychosomatic Medicine and Psychotherapy (AEPM).
The results were published in the Journal of Biophotonics (1-9, 2012) (title: "Comparison of two methods for noninvasive determination of carotenoids in human and animal skin: Raman spectroscopy versus reflection spectroscopy").
We have been working with Prof. Lademann in the field of antioxidant measurement for about 10 years. He is the world's leading scientist in the field of non-invasive measurement of antioxidants. For this reason biozoom had the validation of the measuring device carried out by Prof. Lademann. In the corresponding study it could be shown that the measured values of the biozoom measuring device agree very well with the measured values of a recognized reference system. The results were published in the Journal of Biophotonics (1-9, 2012) (title: “Comparison of two methods for noninvasive determination of carotenoids in human and animal skin: Raman spectroscopy versus reflection spectroscopy“).
Due to the validity of the measured values, the biozoom scanner is also being tested in clinical use. Prof. Lademann uses the system to examine the hand-foot syndrome, which can occur in chemotherapy as a result of certain chemotherapeutic agents. The chemotherapeutic agents get on the skin through the sweat and lead to highly inflammatory processes that have to be treated accordingly.
Another dissertation focused on examining the influence of diet, lifestyle and sociocultural factors on the antioxidant potential.
Prof. John from the University of Osnabrück is using the system successfully in the field of occupational medicine.
In a scientific study by Prof. Lademann / Charité Berlin with 50 schoolchildren it was shown that the measurement of antioxidants leads to a positive change in the user's diet and lifestyle, because the measurement result and behavior are directly linked. If the changes go in the right direction, the measured values increase, which encourages the user to maintain his current behavior, e.g. by eating more fruit and vegetables. If you go in the other direction, it readjusts its behavior until increasing values lead it on the right path. Against this background, the students improved their readings by an average of one point on the scale within a month. To check the steadiness, they were measured again after six months. Compared to the starting value at the beginning of the study, the average values were slightly higher. In addition, 41% of the smokers had given up smoking, since smokers normally have lower measured values than non-smokers. (see Journal of Biophotonics 1-12, 2013 (Title: "Spectroscopic biofeedback on cutaneous carotenoids as part of a prevention program could be effective to raise health awareness in adolescents")). The results show what influence the biofeedback measurement has on current human behavior.
The antioxidant potential of pregnant women and newborns was examined in a dissertation at the University of Rostock. It is known that there is a conditional increase in free radicals during pregnancy and childbirth. Up to 80% of newborn deaths in the first month of life are caused by diseases associated with the formation of free radicals. This investigation showed that during labor and one day after the birth, the mother's antioxidant potential strongly decreased, while the newborn had a significantly higher level. In some cases, the measurements could even be used to predict the due date.
In another study by the University of Rostock, the effects of shift work on midwives were examined with the help of the biozoom measuring device. The result showed an inverse correlation between shift-related stress and antioxidant potential. In other words, the higher the stress caused by shift work, the lower the midwives' antioxidant levels.
The complete study can be downloaded here.
The fact that our antioxidant measurement is medically and scientifically recognized internationally is made clear by its use in NASA's space program. The biozoom measuring devices are part of the “Human Exploration Research Analog (HERA) Campaign” and will be used in the USA for the upcoming experiment “Effects of 30 days of Isolation and Confinement on Hippocampal Volume and Visuo-Spatial Memory” as well as in the international one NASA project in China. The primary goal is to investigate the influence of isolation in the HERA Habitat on the structural and functional plasticity of the brain, cognitive performance and subjective well-being and their relationships with neurophysiological biomarkers. The projects are scientifically supported by the German Aerospace Center (DLR).
In the present study, an improved method based on multiple spatially resolved reflection spectroscopy (MSRRS) was introduced. The results obtained were compared with those obtained using the 'gold standard' resonance Raman spectroscopy method and showed strong correlations for the total carotenoid concentration (R = 0.83) as well as for lycopene (R = 0.80). The measurement stability was confirmed to be better than 10% within the total temperature range from 5 ° C to + 30 ° C and pressure contact between the skin and the MSRRS sensor from 800 Pa to 18,000 Pa.